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KMID : 0861120140180020133
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Korean Journal of Oriental Preventive Medicine
2014 Volume.18 No. 2 p.133 ~ p.145
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The anti-climacterium effects of red clover dry extracts combined with pomegranate concentration powder in ovariectomized rats
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Kim Kyung-Hu
Choi Seong-Hun
Park Soo-Jin
Song Chang-Hyun
Ku Sae-Kwang
Lee Young-Joon
Kang Su-Jin
Choi Beom-Rak
Kim Seung-Hee
Yi Hae-Yeon
Kim Dong-Chul
Han Chang-Hyun
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Abstract
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Objective : In this study, the addition of dried pomegranate concentrate powder (PCP) was affected theanti-climacterium activity of red clover dry extracts (RC) in ovariectomized (OVX) rats.
Materials and methods : After bilateral OVX surgery, RC 40 mg/kg, PCP 20 mg/kg and RC:PCP 2:1 mixture(g/g) 120, 60 and 30 mg/kg (of body weight) were orally administered, once a day for 84 days, and then thechanges on the serum estradiol levels, abdominal fat pad and uterus weights were observed for estrogeniceffects. In addition, liver weights, serum aspartate aminotransferase (AST) and alanine aminotransferase(ALT) levels were also evaluated for hepatoprotective effects, and serum total cholesterol (TC), low densitylipoprotein (LDL), high density lipoprotein (HDL) and triglyceride (TG) levels were monitored for hypolipidemiceffects.
Results : As a result of OVX, the estrogen-deficient climacterium symptoms, increments of abdominal fatpad weights, serum AST, ALT, TC, LDL and TG levels with decrease of uterus and liver weights, serumestradiol levels, were demonstrated. However, these estrogen-deficient climacterium symptoms induced bybilateral OVX in rats were significantly inhibited by continuous oral treatment of RC 40 mg/kg, PCP 20mg/kg and RC:PCP 2:1 mixture (g/g) 120, 60 and 30 mg/kg, respectively.
Conclusion : The results suggested that RC:PCP 2:1 mixtures synergistically increased the anti-climacteriumeffects of RC in OVX rats. It, therefore, is expected that RC:PCP 2:1 mixture will be promising as a newpotent protective agents for relieving the climacterium symptoms.
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KEYWORD
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dried pomegranate concentrate powder, red clover dry extracts, 2:1 mixtures, anticlimacterium effects, ovariectomy, rats
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